| ncRNA name | hsa-let-7a-5p |
| ncRNA Category | miRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | serum; human retinal microvascular endothelial cells (HRMECs) |
| Methods | RNA-seq, qRT-PCR, transfection, CCK-8 assay |
| Expression pattern | up-regulated |
| Functional description | Two-stage analysis verified that a profile of five serum miRNAs (hsa-let-7a-5p, hsa-miR-novel-chr5_15976, hsa-miR-28-3p, has-miR-151a-5p, has-miR-148a-3p) was significantly associated with T2DM-DR. Lentivirus-mediated overexpression of hsa-let-7a-5p in human retinal microvascular endothelial cells (HRMECs) significantly promoted proliferation rates of HRMECs. |
| PubMed ID | 29812988 |
| Year | 2018 |
| Title | RNA sequencing identified specific circulating miRNA biomarkers for early detection of diabetes retinopathy. |
| Drug-related ncRNA | NO |
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